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Continuing pregnancy (less than 1 in 100)
Hemorrhage-very heavy bleeding (2 in 1,000)
Undiagnosed ectopic pregnancy (1 in 7,000)
Psychological problems (variable)
Extra procedures that may be necessary
Surgical abortion or uterine aspiration (3 in 100)
Laparoscopy or laparotomy-operation to look inside the abdomen
Hysterectomy-surgical removal of the womb (2 in 100,000)
Death is very rarely linked to abortion treatment (less than 1 in 100,000 for all abortions).
You will receive your treatment package direct from the pharmacy from 1 to 3 days from your telephone consultation (sometimes longer with Bank Holidays). If your package is delayed in the post for a few days you should still take the tablets as directed once they arrive . The package is plain with no indication of its contents, it will be tracked but not signed for. Your pack will contain:
Mabon pack containing 1 tablet of mifepristone (step 1) and 4 tablets of misoprostol (step 2)
2 plastic-wrapped misoprostol tablets (step 3)
Pregnancy test (step 4)
Codeine (only provided if medically suitable)
Your chosen contraceptive pills, patches, or rings (if requested and suitable)-you will need to supply your height, weight, and blood pressure reading for patches, pills, and combined hormonal pills. Click for details where to get blood pressure readings
STI test-you may also receive a chlamydia and gonorrhea test. Blood affects the results of this test, so it is best to complete this before starting your treatment. Click for details.
This medication is used to prevent stomach ulcers while you take NSAIDs (eg, aspirin, ibuprofen, naproxen), especially if you are at risk for developing ulcers or have a history of ulcers. Misoprostol helps to decrease your risk of serious ulcer complications such as bleeding. This medication protects your stomach lining by lowering the amount of acid that comes in contact with it. This medication is also used in combination with another drug (mifepristone) to end a pregnancy (abortion).
How to use Cytotec
This medicine comes with a patient information leaflet. Read it carefully. If you have any questions about this drug, ask your doctor, nurse, or pharmacist.
Dosage is based on your medical condition and response to therapy.
If you are taking this drug to prevent stomach ulcers, take it by mouth usually four times a day, after meals and at bedtime to minimize diarrhea, or as directed by your doctor.
If you are taking this medication for abortion, take it by mouth exactly as directed by your doctor.
If you are using this medication to start labor, your healthcare professional will insert it into your ******.
Avoid taking antacids that contain magnesium while using misoprostol because they may make diarrhea it causes worse. If you need an antacid, consult your doctor or pharmacist to help you choose a product.
For ulcer prevention, continue to take this drug for as long as you take NSAIDs. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day.
Inform your doctor if your condition persists or worsens.
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List Cytotec side effects by likelihood and severity
Who should not take Cytotec?
What should I know regarding pregnancy, nursing, and administering Cytotec to children or the elderly? What conditions does Cytotec treat? What is Cytotec? Cytotec reduces stomach acid and helps protect the stomach from damage that can be caused by taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.Cytotec is used to prevent stomach ulcers during treatment with aspirin or an NSAID.Cytotec may also be used for purposes not listed in this medication guide.
Warnings///Cytotec can cause birth defects, premature birth, uterine rupture, miscarriage, or incomplete miscarriage, and dangerous uterine bleeding. Do not use this medicine if you are pregnant.
If you are able to become pregnant, you will need to have a negative pregnancy test before starting this treatment. You will also need to use effective birth control to prevent pregnancy during treatment.
Before taking this medicine
You should not use Cytotec if you are allergic to Cytotec or other prostaglandins, or if you are pregnant.
To make sure Cytotec is safe for you, tell your doctor if you have:
inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), or other intestinal problems;
heart disease; or
if you are dehydrated.
FDA pregnancy category X. Cytotec can cause birth defects, premature birth, uterine rupture, miscarriage, or incomplete miscarriage, and dangerous uterine bleeding. Do not use this medicine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine, and for at least 1 month after your treatment ends.
If you are able to become pregnant, you will need to have a negative pregnancy test before you start taking Cytotec. Treatment with this medicine should begin on the second or third day of your menstrual period.
Product is to be used only under the supervision of a service provider and in a medical facility as specified under MTP Act 2002 and MTP Rules 2003.
Qualitative and Quantitative Composition
Each pack contains 5 tablets:
A. 1 Mifepristone Tablet
Each uncoated tablet contains:
Mifepristone… 200 mg
B. 4 Misoprostol Tablets
Each uncoated tablet contains:
Misoprostol… 200 mcg
Dosage Form and Strength
Mifepristone tablet for oral use and misoprostol tablets for ******* use.
MTP Kit is indicated for the medical termination of intrauterine pregnancy of up to 63 days gestation based on the first day of the last menstrual period.
Posology and Method of Administration
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There are no data on the safety and efficacy of mifepristone in women with chronic medical conditions such as cardiovascular, hypertensive, hepatic, respiratory or renal disease; insulin-dependent diabetes mellitus; severe anemia or heavy smoking. Women who are more than 35 years of age and who also smoke 10 or more cigarettes per day should be treated with caution because such patients were generally excluded from clinical trials of mifepristone.
Although there is no clinical evidence, the effectiveness of mifepristone may be lower if misoprostol is administered more than 2 days after mifepristone administration.
Patients with prosthetic heart valves or who have had one previous episode of infective endocarditis should receive appropriate prophylactic antibiotic treatment.
A physical examination must be performed by a qualified trained medical professional in a woman who has undergone genital mutilation to exclude any anatomical obstacles to medical abortion.
During clinical trials, pregnancies occurred between embryo expulsion (abortion) and the resumption of menses. To avoid potential exposure of a subsequent pregnancy to mifepristone, it is recommended that unprotected sexual intercourse be avoided until the appearance of the first menses after the abortion. Reliable contraception should commence as soon as the termination of the pregnancy has been confirmed,
Clinical examination is necessary to confirm the complete termination of pregnancy after the treatment procedure. Changes in quantitative human chorionic gonadotropin (hCG) levels will not be decisive until at least 10 days after the administration of mifepristone. A continuing pregnancy can be confirmed by ultrasonographic scan .
Very rare cases of fatal or serious toxic shock caused by pathogens like Clostridium sordellii endometritis, Escherichia coli presenting with or without fever or other obvious symptoms of infection, have been reported after medical abortion with the use of 200mg mifepristone followed by non-authorized ** ***** administration of misoprostol tablets for oral use. It cannot be excluded that this infection may also occur with ******* misoprostol.
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Although specific drug or food interactions with mifepristone have not been studied, on the basis of this drug’s metabolism by CYP3A4, it is possible that ketoconazole, itraconazole, erythromycin, and grapefruit juice may inhibit its metabolism (increasing serum levels of mifepristone). Furthermore, rifampin, dexamethasone, St. John’s Wort, and certain anticonvulsants (phenytoin, phenobarbital, carbamazepine) may induce mifepristone metabolism (lowering serum levels of mifepristone). Whether this action has an impact on the efficacy of the dose regimen is unknown.
Based on in vitro inhibition information, co-administration of mifepristone may lead to an increase in serum levels of drugs that are CYP3A4 substrates. Due to the slow elimination of mifepristone from the body, such interaction may be observed for a prolonged period after its administration Therefore, caution should be exercised when mifepristone is administered with drugs that are CYP3A4 substrates and have narrow therapeutic range, including some agents used during general anaesthesia.
Misoprostol has not been shown to interfere with the beneficial effects of aspirin on signs and symptoms of rheumatoid arthritis. Misoprostol does not exert clinically significant effects on the absorption, blood levels, and antiplatelet effects of therapeutic doses of aspirin.
Misoprostol is predominantly metabolized via fatty acid oxidizing systems and has shown no adverse effect on the hepatic microsomal mixed function oxidase (P450) enzyme system. In specific studies, no clinically significant pharmacokinetic interaction has been demonstrated with antipyrine or diazepam. A modest increase in propranolol Concentrations (mean approximately 20% in AUC, 30% in Cmax) has been observed with multiple dosing of misoprostol. In extensive clinical studies no drug interactions have been attributed to misoprostol. Drug interaction studies with misoprostol and several NSAIDs showed no clinically significant effect on the kinetics of ibuprofen, diclofenac, piroxicam, aspirin, naproxen or indomethacin. Concomitant administration of NSAIDs and misoprostol in rare cases can cause a transaminase increase and peripheral oedema.
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Do not share this medicine with another person.
Cytotec is usually taken with meals and at bedtime. Follow your doctor’s instructions.
You may have nausea, stomach cramps, or diarrhea while taking this medicine, especially during the first few weeks after you start taking Cytotec. These symptoms usually last for about a week.
Call your doctor if you have severe nausea, stomach pain, or diarrhea lasting longer than 8 days.
Read all medication guides or patient instructions provided with this medicine each time you receive a new supply.
Store at room temperature away from moisture and heat.
Detailed Cytotec dosage information
What happens if I miss a dose?
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.
What happens if I overdose?
MTP Kit (Mifepristone + Misoprostol)
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